AZD 1678( AZD1678 | AZD-1678 )

Catalog No. M16739 CAS No. 942137-41-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AZD 1678
Note

Research use only, not for human use.
Brief Description

AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4.
Description

AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4; shows no significant activity against a panel of chemokine receptors (CXCR1, CXCR2, CCR1, CCR2b, CCR5, CCR7, CCR8; inactive at 10 uM); inhibits Th2 cell CCL22 driven chemotaxis in 0.3% HSA with pIC50 of 6.8.Asthma Phase 1 Clinical.
In Vitro

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In Vivo

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Synonyms

AZD1678 | AZD-1678
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

Inflammation/Immunology
Indication

Asthma

CAS Number

942137-41-9
Formula Weight

352.1614
Molecular Formula

C11H8Cl2FN3O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=C(F)N=C2OC)=O
Chemical Name

2,3-Dichloro-N-(5-fluoro-3-methoxy-2-pyrazinyl)benzenesulfonamide

1. Kindon N, et al. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986.

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